At a glance
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Multimodal Pain Treatment for Breast Cancer Surgery - a Prospective Cohort Study
In Brief
An observational study evaluating Standardised multimodal pain treatment regimen for Breast Cancer Female and 2 related conditions. Completed, enrolled 236 participants across 1 site.
Detailed Summary
Breast cancer is one of the most common types of cancer among women worldwide. (1) Breast-conserving surgery or mastectomy is indicated for the majority of patients with this type of cancer. (2) Postoperative pain is frequent in this population, with almost 50 % experiencing acute pain and 25-60 % subsequently live with chronic pain. (3-5) Today no golden standard for postoperative pain management regarding breast cancer surgeries exists, and there is definitely room for improvement. Especially considering the large population of women with breast cancer and consequences of acute and chronic pain, such as prolonged recovery and affected quality of life. (6,7) With the present study, we aim to optimise postoperative pain treatment and investigate the effect of a standardised multimodal postoperative analgesic regimen based on previous recommendations. (4,8,9)
Study Details
Timeline
Interventions
Preoperatively: * Paracetamol 1000 mg p.o. * Celecoxib 400 mg p.o. * Dexamethasone 12 mg p.o. Perioperatively: * Ondansetron 4 mg IV * Bupivacaine 2.5 mg/mL, 20 mL LIA * Oxycodone 0.15 mg/kg IV (Oxycodone 0.25 mg/kg for ALND) Postoperatively: * Paracetamol 1000 mg p.o. every 6h PRN * Ibuprofen 400 mg p.o. every 6h (day 1-5) PRN * Oxycodone 5 mg IV or 10 mg p.o. PRN * Ondansetron 4 mg IV or p.o. PRN