CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 265 enrolled
Drug / intervention
Intervention Arm: dolutegravir/lamivudine +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04880395
NCT04880395Phase 4Completed

Dolutegravir-Lamivudine for naïve HIV-Infected Patients With ≤200 CD4/mm3

Fundación Huésped·interventional·Posted May 10, 2021·Updated Jul 30, 2025

In Brief

A Phase 4 clinical trial evaluating Intervention Arm: dolutegravir/lamivudine and Comparator ARM: TDF/XTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine) for HIV-1-infection. Completed, enrolled 265 participants across 11 sites in 2 countries.

Detailed Summary

Protocol Title: DOLCE: Dolutegravir-Lamivudine for naïve HIV-Infected Patients with ≤200 CD4/mm3 Protocol Number: FH-57 Study Objectives: To assess the antiviral activity at week 48 of DTG+3TC among naïve HIV patients with a CD4 count ≤200 cells /mm3.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHIV-1-infection
CountriesArgentina, Brazil

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedMay 10, 2021
Enrollment StartMay 17, 2021
Primary CompletionMay 7, 2024
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 5.1 years ago

Interventions

Intervention Arm: dolutegravir/lamivudinedrug

1 pill QD

Comparator ARM: TDF/XTC plus Dolutegravir (XTC stand for lamivudine OR emtricitabine)drug

1 pill of each QD