CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 42 enrolled
Drug / intervention
Sacubitril / Valsartan Oral Tablet [Entresto] +1 moredrug
Likely dose
Sacubitril / Valsartan Oral Tablet [Entresto] 26 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04883528
NCT04883528Phase 2Completed

Protecting With ARNI Against Cardiac Consequences of Coronavirus Disease 2019

Duke University·interventional·Posted May 12, 2021·Updated Jul 3, 2024

In Brief

A Phase 2 clinical trial evaluating Sacubitril / Valsartan Oral Tablet [Entresto] and Placebo for Covid19. Completed, enrolled 42 participants across 1 site.

Detailed Summary

The purpose of this study is to determine the effect of sacubitril/valsartan versus placebo on markers of cardiac injury, structure, and function among patients who recovered from acute COVID-19 infection.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCovid19
CountriesUnited States

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedMay 12, 2021
Enrollment StartAug 6, 2021
Primary CompletionJun 13, 2023
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 5.1 years ago

Interventions

Sacubitril / Valsartan Oral Tablet [Entresto]drug

sacubitril/valsartan (LCZ696) tablet with minimum dose 24/26 mg, maximum dose 97/103 mg twice daily administered orally.

Placebodrug

sacubitril/valsartan matching placebo tablet with minimum dose 24/26 mg, maximum dose 97/103 mg twice daily administered orally.