CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 165 enrolled
Drug / intervention
Pacritinibdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04884191
NCT04884191Phase 2Completed

Phase 2 Study: An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post- Essential Thrombocythemia Myelofibrosis Previously Treated With Ruxolitinib

CTI BioPharma·interventional·Posted May 12, 2021·Updated Jun 1, 2022

In Brief

A Phase 2 clinical trial evaluating Pacritinib for Primary Myelofibrosis and 2 related conditions. Completed, enrolled 165 participants across 62 sites in 8 countries.

Detailed Summary

This was an open-label, randomized, dose-finding study in patients with primary or secondary MF (Dynamic International Prognostic Scoring System \[DIPSS\] risk score of Intermediate-1 to High-Risk) who were previously treated with ruxolitinib. The study was designed to support a pacritinib dosage selection decision with evaluation of 3 dosages.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesFrance, Hungary, Italy, South Korea, Spain, Sweden, United Kingdom, United States
Collaborators--

Timeline

Phase 2CompletedFinished
201820192020202120222023202420252026
First PostedMay 12, 2021
Enrollment StartJul 31, 2017
Primary CompletionSep 4, 2019
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 5.1 years ago

Interventions

Pacritinibdrug

Pacritinib