At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Insulin Resistance on Branched Chain Amino Acid Metabolism.
In Brief
A clinical study evaluating Administration of an 8% crystalline L-amino acid solution with high concentrations of branched chain amino acids. for Obesity and Insulin Resistance. Completed, enrolled 40 participants across 1 site.
Detailed Summary
It has been observed that subjects with obesity and insulin resistance have higher concentrations of branched chain amino acids in plasma or serum. However, this association has been established under fasting conditions, so they only give information about a metabolic state and do not reflect the dynamics and flexibility of the metabolism of these amino acids in the absence or presence of insulin resistance. The main aim of this study is to compare the catabolism of branched chain amino acids and their keto acids in subjects with and without insulin resistance, after the infusion of an amino acid solution with high concentration of the branched chain amino acids, leucine, valine, and isoleucine. The results of this project will allow the investigators to understand the dynamics of the branched chain amino acids and their derivatives, and its relationship with insulin resistance, which could eventually be used to design nutritional strategies to treat insulin resistance and thus, delay the development of type 2 diabetes.
Study Details
Timeline
Interventions
Intravenous administration of 8% crystalline L-amino acids with high concentrations of branched chain amino acids.