CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 133 enrolled
Drug / intervention
Best Practice +5 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04888988
NCT04888988N/AActive

Multi-Center Randomized Controlled Phase II Trial of Exercise to Treat Chemotherapy-Induced Peripheral Neuropathy (CIPN)

University of Rochester NCORP Research Base·interventional·Posted May 17, 2021·Updated Apr 24, 2026

In Brief

A clinical study evaluating Best Practice, Exercise Counseling, and 4 other interventions for Chemotherapy-Induced Peripheral Neuropathy and 2 related conditions. Active but no longer recruiting, targeting 133 participants across 93 sites.

Detailed Summary

This phase II trial studies whether using exercise is better than the usual approach for treating chemotherapy-induced peripheral neuropathy (CIPN). CIPN occurs when chemotherapy damages the nerves communicating between the brain, spinal cord, and the rest of the body. The usual approach for treating CIPN is treatment with drugs that help reduce symptoms of other types of neuropathy (for example, from diabetes). However, these drugs do not treat all symptoms of CIPN. Exercise may help to reduce CIPN symptoms.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/AActiveOverdue
20222023202420252026
First PostedMay 17, 2021
Enrollment StartFeb 25, 2022
Primary CompletionOct 20, 2025
Study CompletionJun 30, 2026
TodayJul 2, 2026
Enrollment to primary: 3.7 yearsPosted 5.1 years ago

Interventions

Best Practiceother

Receive standard of care

Exercise Counselingother

Meet with certified exercise instructor

Exercise Interventionother

Participate in the EXCAP program

Magnetic Resonance Imagingprocedure

Undergo MRI

Neuropathy Assessmentother

Undergo tactile sensitivity test

Questionnaire Administrationother

Ancillary studies