At a glance
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Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD: A Pilot Study
In Brief
A Phase 2 clinical trial evaluating Ketamine and Written Exposure Therapy for PTSD. Completed, enrolled 16 participants across 1 site.
Detailed Summary
The current pilot project will evaluate the efficacy of adding Written Exposure Therapy (WET) to a course of repeated IV ketamine infusions in improving PTSD symptoms and maintaining symptom improvement in patients with chronic PTSD. WET is a brief, 5-session evidence-based written trauma-focused therapy without in between-session assignments, with demonstrated efficacy and low dropout rates in patients with PTSD. WET will be administered to all eligible participants; the first WET sessions will be interleaved with the last two ketamine infusions to take advantage of a window of increased neuroplasticity potentially induced by repeated ketamine infusions. WET will be administered on different days as the ketamine infusions.
Study Details
Timeline
Interventions
Repeated intravenous Ketamine infusions.
WET is a brief, 5-session evidence-based written trauma-focused therapy