CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Acute Intermittent Hypoxiaprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04890639
NCT04890639N/ACompleted
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Safety and Cognitive Effects of Acute Intermittent Hypoxia-Induced Neuroplasticity in Traumatic Brain Injury

Shirley Ryan AbilityLab·interventional·Posted May 18, 2021·Updated Feb 18, 2026

In Brief

A clinical study evaluating Acute Intermittent Hypoxia for Brain Injuries, Traumatic. Completed, enrolled 12 participants across 1 site.

Detailed Summary

This study is designed to answer questions related to safety and preliminary efficacy of Acute Intermittent Hypoxia (AIH) in Traumatic Brain Injury (TBI) survivors. First, we aim to establish whether brief reductions in inhaled oxygen concentration can be safely tolerated in TBI survivors. Second, we aim to establish whether there are any effects of AIH on memory, cognition, and motor control. Participants will be monitored closely for any adverse events during these experiments. Data will be analyzed to determine if there is an improvement in key outcomes at any dose level.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Injuries, Traumatic
CountriesUnited States
CollaboratorsNational Institute of Neurological Disorders and Stroke (NINDS)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedMay 18, 2021
Enrollment StartMar 15, 2022
Primary CompletionJan 29, 2024
TodayJul 2, 2026
Enrollment to primary: 1.9 yearsPosted 5.1 years ago

Interventions

Acute Intermittent Hypoxiaprocedure

Four hypoxia sessions, consisting of 15 cycles of hypoxia (21%, 17%, 13% or 9% O2), each of which lasts up to 60 seconds, interspersed with up to 90-second normoxic episodes.