CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 36 enrolled
Drug / intervention
Guided tissue regeneration (GTR) +1 moreprocedure
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04896450
NCT04896450N/ACompleted
CompareCT.gov

Comparison of the Guided Tissue Regeneration (GTR) Procedure Alone and in Combination With Immediate Orthodontic Tooth Movement (OTM) in the Treatment of Non-containing and Wide Intrabony Periodontal Defects: a Prospective RCT

Semmelweis University·interventional·Posted May 21, 2021·Updated Feb 21, 2023

In Brief

A clinical study evaluating Guided tissue regeneration (GTR) and Orthodontic tooth movement (OTM) for Intrabony Periodontal Defect. Completed, enrolled 36 participants across 1 site.

Detailed Summary

The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone. Clinical, radiological and reentry (histological) evaluation of a regenerative surgical method (GTR + grafting material) with different postsurgical healing patterns in the treatment of wide, non-containing intrabony defects.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsIntrabony Periodontal Defect
CountriesHungary
CollaboratorsSchupbach Ltd., Geistlich Pharma AG

Timeline

N/ACompletedFinished
20162017201820192020202120222023202420252026
First PostedMay 21, 2021
Enrollment StartSep 1, 2015
Primary CompletionDec 1, 2022
TodayJul 2, 2026
Enrollment to primary: 7.3 yearsPosted 5.1 years ago

Interventions

Guided tissue regeneration (GTR)procedure

GTR is handled with the utilization of a coronally advanced flap, followed by a thorough debridement of the denudated root surface and the intrabony component. Regenerative materials are resorbable collagen membrane (BioGide, Geistlich Phara AG, Wolhusen, Switzerland) and deproteinized bovine bone mineral (BioOss, Geistlich Phara AG), finally surgery is finished with multilayer suturing technique.

Orthodontic tooth movement (OTM)device

An early initialization of the tooth movement with the help of a multibond fixed orthodontic device utilizing low level of continuous orthodontic forces.