At a glance
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The Effect of Dietary Fructose on Gut Microbiota and Hepatosteatosis in Healthy Men
In Brief
A clinical study evaluating 75g fructose solution and 150g fructose solution for Hepatic Steatosis and Dietary Fructose Exposure. Completed, enrolled 58 participants across 1 site.
Detailed Summary
The consumption of sugar-sweetened beverages (SSB) has increased steadily over the past decades, resulting in the dramatic increase of fructose intake as it is one of the main ingredients of artificial sweeteners. Recently, large epidemiological studies have documented the association between a high-fructose-diet and hepatic steatosis, and other metabolic disorders. So it is interesting for scientists to explore the underlying mechanism. This study aims to investigate the effect of dietary fructose and gut microbiota and the hepatosteatosis in healthy men. Serum and fecal metabolomics will be investigated.
Study Details
Timeline
Interventions
Subjects will drink a bottle of 350 ml solution containing 75g fructose per day for 4 weeks.
Subjects will drink a bottle of 700 ml solution containing 150g fructose per day for 4 weeks.