CI

At a glance

ClinicalIndex Comparison Record
N/AActive· 225 target
Drug / intervention
In-person training for seed placement and APA +3 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04920097
NCT04920097N/AActiveUpdate OverdueUpdated 6mo ago · Completion was 13mo ago
Enrollment Stalled
CompareCT.gov

Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy

The University of Texas Health Science Center, Houston·interventional·Posted Jun 9, 2021·Updated Dec 15, 2025

In Brief

A clinical study evaluating In-person training for seed placement and APA, Virtual training for seed placement and APA, and 2 other interventions for Chemotherapy-induced Neuropathy. Active but no longer recruiting, targeting 225 participants across 2 sites.

Signals

Enrollment appears stalled

Detailed Summary

The proposed randomized control trial will evaluate auricular point acupressure (APA) on chemotherapy-induced neuropathy (CIN), rigorously considering point specificity and placebo effects by integrating self-report measures, psychophysical measures (QST), endogenous biomarkers (cytokines), and neuro-imaging to investigate APA's efficacy and underlying mechanism(s).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChemotherapy-induced Neuropathy
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI), Johns Hopkins University

Timeline

N/AActiveOverdue
20222023202420252026
First PostedJun 9, 2021
Enrollment StartJul 8, 2021
Primary CompletionMay 30, 2025
Study CompletionMay 30, 2026
TodayJul 2, 2026
Enrollment to primary: 3.9 yearsPosted 5.1 years ago

Interventions

In-person training for seed placement and APAother

In-person seed placement and a training for the participant or their caregiver to place the seeds on the ear points.

Virtual training for seed placement and APAother

Self-administer APA by placing the seeds according to the video instruction found in the self-guided smartphone application for understanding and administering APA. Participant and/or a caregiver will follow the video instruction on seed placement.

Usual Careother

Participants will continue with usual care from oncologist.

Post-training zoom session for seed placement and APA coachingother

Zoom session for seed placement and APA coaching, to occur after initial APA and seed placement training (initial training is either in person or guided by the smartphone app videos).