At a glance
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Effectiveness of Combined Levetiracetam and Midazolam in Treatment of Generalized Convulsive Status Epilepticus in Children
In Brief
A Phase 2 clinical trial evaluating Levetiracetam, Midazolam, and 1 other intervention for Status Epilepticus and 3 related conditions. Completed, enrolled 144 participants across 1 site.
Detailed Summary
Generalized status epilepticus is a common pediatric neurological emergency with significant mortality and morbidity. Benzodiazepines remain the first anticonvulsive line but benzo-diazepines don't control seizures in about 30% of cases. GCSE may be more rapidly stopped and controlled through combining another drug with benzodiazepines such as Levetiracetam, acting by different pathways. This study aims to evaluate the effectiveness of combined levetiracetam and midazolam in treatment of generalized convulsive status epilepticus in children.
Study Details
Timeline
Interventions
Intravenous levetiracetam 60 mg/kg (max 4500 mg) over 5 minutes (diluted with isotonic saline to a concentration of 50 mg/ml).
Intravenous midazolam 0.2 mg/kg (maximum 10 mg) over 2 minutes
Intravenous isotonic saline (1.2 ml/kg) over 5 minutes