CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 568 enrolled
Drug / intervention
Yellow fever vaccine (produced on serum-free Vero cells) +1 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04942210
NCT04942210Phase 2Active
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Controlled Study of Immunogenicity and Safety of the Investigational vYF Candidate Vaccine in Comparison to YF-VAX in Adults

Sanofi Pasteur, a Sanofi Company·interventional·Posted Jun 28, 2021·Updated Jun 18, 2025

In Brief

A Phase 2 clinical trial evaluating Yellow fever vaccine (produced on serum-free Vero cells) and Yellow fever vaccine for Yellow Fever and Healthy Volunteers. Active but no longer recruiting, targeting 568 participants across 11 sites.

Detailed Summary

The primary objective of the study is to demonstrate the non-inferiority of the antibody response in terms of seroconversion rate 28 days after vaccine administration of one dose of yellow fever vaccine (vYF) compared to the antibody response after one dose of the YF-VAX control vaccine in yellow fever naïve participants. The secondary objectives of the study are: * To describe the immune response to yellow fever in both vaccine groups before and after vYF or YF-VAX administration. * To describe the safety profile of vYF vaccine in comparison to the safety profile of the control YF-VAX. * To describe the biosafety profile of vYF in comparison to the biosafety profile of the control YF-VAX.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsYellow Fever, Healthy Volunteers
CountriesUnited States
Collaborators--

Timeline

Phase 2Active
202220232024202520262027
First PostedJun 28, 2021
Enrollment StartJul 1, 2021
Primary CompletionJun 24, 2022
Study CompletionJun 29, 2027
TodayJul 2, 2026
Enrollment to primary: 12 monthsPosted 5.0 years ago

Interventions

Yellow fever vaccine (produced on serum-free Vero cells)biological

Powder and diluent for suspension for injection Subcutaneous injection

Yellow fever vaccinebiological

Powder and diluent for suspension for injection Subcutaneous injection