CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 120 enrolled
Drug / intervention
Adaptive messaging intervention +3 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04948268
NCT04948268N/ACompleted

Digital Mental Health Service for Non-Treatment Seeking Young Adults

Northwestern University·interventional·Posted Jul 1, 2021·Updated Feb 9, 2026

In Brief

A clinical study evaluating Adaptive messaging intervention, Non-personalized messaging intervention, and 2 other interventions for Depression and 2 related conditions. Completed, enrolled 120 participants across 1 site.

Detailed Summary

This is a feasibility trial of a personalized 8-week text messaging intervention aimed at young adults (ages 18-25) with depression and anxiety who are not interested in -- or experience barriers to -- receiving traditional face-to-face psychological treatments. The trial will consist of a pilot test of (1) an 8-week adaptive (personalized) messaging intervention relative to (2) a non-personalized digital mental health intervention, or (3) an active control which will send weekly psychoeducation information by way of Uniform Resource Locators (URLs). The adaptive intervention will uses machine learning to tailor Short Message Service (SMS) messages to an individual's needs and preferences, and URL links to provide access to psychoeducational content to contextualize messages, when the length of that content exceeds the limitations of messages. The primary goals of the project are to conduct a feasibility trial using a sequential multiple assignment randomized treatment (SMART) design, which will evaluate (a) the effectiveness of an adaptive, personalized messaging intervention in reducing engagement relative to a non-personalized version; and (b) whether human coaching results in greater symptom reduction and engagement, relative an unguided implementation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJul 1, 2021
Enrollment StartOct 27, 2023
Primary CompletionOct 23, 2024
Study CompletionOct 25, 2024
TodayJul 2, 2026
Enrollment to primary: 12 monthsPosted 5.0 years ago

Interventions

Adaptive messaging interventionbehavioral

Psychological content and messages delivered regularly over an 8-week period via interactive SMS messages. Content and messages will be tailored using machine learning.

Non-personalized messaging interventionbehavioral

Psychological content and messages delivered regularly over an 8-week period via interactive SMS messages. Psychological content will center on a single psychological strategy each week. There will not be any tailoring of messaging and content based on group or individual level data.

Coachingbehavioral

Human coaching to support intervention use and engagement via telephone calls, text or email

Psychoeducational linksbehavioral

SMS messages with URLs containing brief psychoeducational information.