CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 60 enrolled
Drug / intervention
Cognitive Reappraisal by Distancing +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04967222
NCT04967222N/ACompleted

Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients

Icahn School of Medicine at Mount Sinai·interventional·Posted Jul 19, 2021·Updated Aug 5, 2025

In Brief

A clinical study evaluating Cognitive Reappraisal by Distancing and Control Downregulate Condition for Borderline Personality Disorder. Completed, enrolled 60 participants across 1 site.

Detailed Summary

Previous work by the study group convinced the study team to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJul 19, 2021
Enrollment StartDec 1, 2021
Primary CompletionJun 3, 2024
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 5.0 years ago

Interventions

Cognitive Reappraisal by Distancingbehavioral

Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique. .

Control Downregulate Conditionbehavioral

Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures.