CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 291 enrolled
Drug / intervention
Simplify Discdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT04980378
NCT04980378N/ACompleted

Post Approval Study Protocol for the Two Level Simplify® Cervical Artificial Disc

NuVasive·observational·Posted Jul 28, 2021·Updated Jan 8, 2026

In Brief

An observational study evaluating Simplify Disc for Cervical Degenerative Disc Disorder. Completed, enrolled 291 participants across 18 sites.

Detailed Summary

This study is intended to demonstrate the 5-year long-term safety and efficacy of the Simplify® Cervical Artificial Disc ("Simplify Disc") in subjects enrolled in the non-randomized two-level Simplify Disc Investigational Device Exemption (IDE) study. This study was conducted under IDE G150206

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJul 28, 2021
Enrollment StartAug 1, 2021
Primary CompletionJan 24, 2024
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 4.9 years ago

Interventions

Simplify Discdevice

The Simplify Disc is a cervical artificial disc manufactured from polyether ether ketone (PEEK) endplates and a mobile, zirconia-toughened alumina ceramic core.