CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 12 enrolled
Drug / intervention
Healsea® Chronic, hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extractdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05015530
NCT05015530N/ACompleted

Assessment of Sino-nasal Microbial Communities Changes in Adult Patients With Chronic Rhinosinusitis by 16 rRNA Gene Amplicon Sequencing Before and After 1-month Treatment Duration With Healsea® Chronic: an Exploratory Study

Lallemand Pharma AG·observational·Posted Aug 20, 2021·Updated Nov 8, 2024

In Brief

An observational study evaluating Healsea® Chronic, hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract for Rhinosinusitis Chronic and Microbiome. Completed, enrolled 12 participants across 1 site.

Detailed Summary

Healsea® chronic is CE marked medical device indicated in adults for the treatment of nasal symptoms of chronic rhinosinusitis. This is an hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extract (0.2%) isolated from marine bacteria. In vitro, Symbiofilm® inhibits at early stage biofilm formation from bacteria found to be more prevalent and abundant in CRS patients (e.g. Staphylococcus aureus, Pseudomonas aeruginosa). This exploratory study is designed with aim to determine if the antibiofilm properties of Symbiofilm® may modify sino-nasal microbiota, impacting α and/ or β diversities.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
CountriesFrance
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedAug 20, 2021
Enrollment StartDec 12, 2022
Primary CompletionMay 19, 2023
TodayJul 2, 2026
Enrollment to primary: 5 monthsPosted 4.9 years ago

Interventions

Healsea® Chronic, hypertonic seawater-based nasal spray supplemented with natural Symbiofilm® extractdevice

Healsea® Chronic nasal spray will be administered twice daily (1 puff, 1-2 sec) in each nostril during 30 days