CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 18 enrolled
Drug / intervention
Lexically based speech recastbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05016037
NCT05016037N/ACompleted

Predictors of Speech Ability in Down Syndrome

Vanderbilt University Medical Center·interventional·Posted Aug 23, 2021·Updated Aug 3, 2025

In Brief

A clinical study evaluating Lexically based speech recast for Speech Intelligibility Intervention in Down Syndrome. Completed, enrolled 18 participants across 1 site.

Detailed Summary

Speech is a critical aspect of the human experience and usually develops in a "seemingly automatic process that continues from birth through adolescence and underlies many related abilities" (e.g., language and reading, see National Academy of Medicine Report on Speech and Language Disorders, 2016). Many individuals with Down Syndrome (Trisomy 21, DS) struggle to communicate and participate more fully in human communication and educational learning experiences because their speech is difficult to understand. The purpose of the proposed project was to measure speech-articulation accuracy and speech intelligibility, and their proposed primary predictors at study entry in 16 children with DS age 4;0 to 17;11). A validated treatment, speech recast intervention (see Yoder, Camarata \& Woynaroski, 2016) was used to drive growth in speech intelligibility as a means of evaluating changes in potential sequelae of change. This study included measures of speech-articulation accuracy, and speech-prosody skills as predictors of speech intelligibility growth in DS.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20222023202420252026
First PostedAug 23, 2021
Enrollment StartFeb 14, 2022
Primary CompletionApr 30, 2024
Study CompletionApr 30, 2025
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 4.9 years ago

Interventions

Lexically based speech recastbehavioral

A child's spontaneous or elicited word production containing phonological errors is immediately followed with a clinician verbal model that corrects the error(s) at the word level rather than the isolated phoneme level. As an example, a speech recast of child's production of the word "bake" as \[be\] would be the whole lexeme bake \[bek\] rather than production drill on \[k\] in isolation.