At a glance
ClinicalIndex Comparison Record- ✓Age ≥18 years
- ✓Primary high-grade glioma (WHO grade III-IV, including glioblastoma), IDH and MGMT status independent
- ✓Prior biopsy confirming high-grade glioma eligible
- ✓Planned neurosurgical resection of tumor
- ✕Pregnant women
- ✕Nursing women unwilling to cease during therapy
- ✕Men or women of childbearing potential unwilling to use adequate contraception
- ✕Prior history of cranial radiotherapy
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Preoperative Radiosurgery in High Grade Glioma: A Phase I Clinical Trial: The NeoGlioma Study
In Brief
A Phase 1 clinical trial evaluating Radiation Therapy, Radiosurgery, and 7 other interventions for Malignant Glioma. Currently recruiting, targeting 28 participants across 2 sites.
Signals
Detailed Summary
This phase I trial finds out the possible benefits and/or side effects of radiosurgery before surgery (preoperative) in treating patients with high grade glioma. Radiosurgery uses special equipment to position the patient and precisely give a single large dose of radiation to the tumor. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pre-operative radiosurgery may improve the odds of brain tumor control and reduce treatment-related side effects.
Study Details
Timeline
Interventions
Undergo radiation therapy
Undergo radiosurgery
Undergo MRI-guided stereotactic biopsy
Drug
Undergo TTF
Undergo MRI
Undergo blood sample collection
Undergo biopsy
Undergo surgery