CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 455 enrolled
Drug / intervention
LOU064 (blinded) +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05032157
NCT05032157Phase 3Completed

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase 3 Study of Remibrutinib (LOU064) to Investigate the Efficacy, Safety and Tolerability for 52 Weeks in Adult Chronic Spontaneous Urticaria (CSU) Patients Inadequately Controlled by H1-antihistamines

Novartis Pharmaceuticals·interventional·Posted Sep 2, 2021·Updated Apr 8, 2025

In Brief

A Phase 3 clinical trial evaluating LOU064 (blinded), Placebo, and 1 other intervention for Chronic Spontaneous Urticaria. Completed, enrolled 455 participants across 122 sites in 18 countries.

Detailed Summary

The purpose of this study was to establish the efficacy, safety, and tolerability of Remibrutinib 25 mg b.i.d. in adult patients suffering from chronic spontaneous urticaria (CSU) inadequately controlled by second generation H1-antihistamines (H1-AHs) in comparison to placebo.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustria, Brazil, Canada, China, Denmark, Germany, India, Malaysia, Poland, Russia, Slovakia, South Africa, Switzerland, Taiwan, Thailand, United Kingdom, United States, Vietnam
Collaborators--

Timeline

Phase 3CompletedFinished
20222023202420252026
First PostedSep 2, 2021
Enrollment StartDec 1, 2021
Primary CompletionDec 18, 2023
Study CompletionJan 5, 2024
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 4.8 years ago

Interventions

LOU064 (blinded)drug

LOU064 (blinded) active treatment

Placebodrug

Placebo

LOU064 (open-label)drug

LOU064 (open-label) active treatment