CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 40 enrolled
Drug / intervention
SPECTRUM NRC 102/103 investigational cigarettes +1 moreother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05032755
NCT05032755N/ACompleted
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Using Very Low Nicotine Cigarettes to Disrupt the Pain-smoking Reinforcement Cycle

Duke University·interventional·Posted Sep 2, 2021·Updated Aug 29, 2025

In Brief

A clinical study evaluating SPECTRUM NRC 102/103 investigational cigarettes and SPECTRUM NRC 600/601 investigational cigarettes for Chronic Pain and Smoking, Cigarette. Completed, enrolled 40 participants across 1 site.

Detailed Summary

The purpose of this study is to evaluate the effects of switching to very low nicotine content (VLNC) cigarettes versus normal nicotine content (NNC) cigarettes on experiences with craving, withdrawal, and pain among individuals with chronic back pain who smoke cigarettes daily.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsChronic Pain, Smoking, Cigarette
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedSep 2, 2021
Enrollment StartJun 23, 2022
Primary CompletionJul 4, 2024
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 4.8 years ago

Interventions

SPECTRUM NRC 102/103 investigational cigarettesother

Very low nicotine content (nonmenthol/menthol) SPECTRUM investigational cigarettes

SPECTRUM NRC 600/601 investigational cigarettesother

Normal nicotine content (nonmenthol/menthol) SPECTRUM investigational cigarettes