CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 16 enrolled
Drug / intervention
Cognitive Behavioral Therapy (CBT) +1 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05041361
NCT05041361N/ACompleted
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HypErthermia as an Additional Treatment for the Biology and Experience of Depression: The HEATBED Study

University of California, San Francisco·interventional·Posted Sep 13, 2021·Updated May 27, 2026

In Brief

A clinical study evaluating Cognitive Behavioral Therapy (CBT) and Whole-Body Hyperthermia (WBH) for Major Depressive Disorder. Completed, enrolled 16 participants across 1 site.

Detailed Summary

This single-arm feasibility trial administered up to 8 weekly (early phase) or 4 bi-weekly (later phase) whole-body hyperthermia (WBH) sessions and 8 weekly cognitive behavioral therapy (CBT) sessions to adults aged 18 years or older with major depressive disorder (MDD).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder
CountriesUnited States
CollaboratorsNational Center for Complementary and Integrative Health (NCCIH)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedSep 13, 2021
Enrollment StartOct 11, 2021
Primary CompletionMar 1, 2023
TodayJul 2, 2026
Enrollment to primary: 1.4 yearsPosted 4.8 years ago

Interventions

Cognitive Behavioral Therapy (CBT)behavioral

Cognitive Behavioral Therapy (CBT) is a behavioral (psychotherapeutic) intervention for major depressive disorder (MDD). A highly trained masters' or PhD-level clinician will administer 8 weekly CBT sessions (\~50 minutes each), following the standard cognitive behavioral therapy for depression protocol.

Whole-Body Hyperthermia (WBH)device

Whole-body hyperthermia (WBH) will be administered by trained research assistants. Preparation for the WBH, the WBH session, and cool down will last 3.5-4 hours, with active WBH lasting up to approximately 140 minutes. WBH will take place in an infrared sauna dome, and the active heating phase will last until the participants has achieved a core (rectal) temperature of 101.3 F.