At a glance
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Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder
In Brief
A clinical study evaluating Theta Burst Stimulation and Sham TMS for Opioid-use Disorder and Tobacco Use Disorder. Completed, enrolled 23 participants across 1 site.
Detailed Summary
The goal of this study is to examine the effect of four sessions of theta burst stimulation (TBS) versus sham TMS on attentional bias for smoking and opioid cues versus neutral stimuli in a population of patients with tobacco use disorder (TUD) with comorbid opioid use disorder (OUD) that is stable and on treatment with buprenorphine. The investigators will also examine the effect of TBS on craving for cigarettes as well as opioids. Participants will perform a stress induction procedure that mirrors an optimum combination of cues that trigger tonic craving in their environment while exposed to stress. All four sessions of TBS/sham TMS will be performed on the same day, with each session lasting for approximately 10 minutes and separated by 50 minute intervals.
Study Details
Timeline
Interventions
Four sessions of theta burst stimulation (TBS) at 120 % RMT and comprising 7200 pulses, given with functional targeting.
Four sessions of sham TMS, done using the A/P MagVenture coil, with subject's head separated from the coil by foam padding.