CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 70 enrolled
Drug / intervention
ACE Inhibitors and Diuretics +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05049616
NCT05049616Phase 4Completed

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension: A Comparative Effectiveness Pilot Randomized Controlled Trial

The University of Texas Health Science Center, Houston·interventional·Posted Sep 20, 2021·Updated Nov 10, 2025

In Brief

A Phase 4 clinical trial evaluating ACE Inhibitors and Diuretics and NIFEdipine ER for Hypertension in Pregnancy and Postpartum Preeclampsia. Completed, enrolled 70 participants across 1 site.

Detailed Summary

The purpose of this study is to see if a combined pill of Angiotensin-converting enzyme (ACE) inhibitors (a medication that helps relax your veins and arteries to lower your blood pressure) with diuretics (sometimes called water pills, help rid your body of salt and water) will control blood pressure better than a different blood pressure medication of calcium channel blocker (lower your blood pressure by preventing calcium from entering the cells of your heart and arteries). Both medications are part of our usual care for high blood pressure after delivery.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedSep 20, 2021
Enrollment StartOct 18, 2021
Primary CompletionJun 26, 2022
Study CompletionSep 1, 2023
TodayJul 2, 2026
Enrollment to primary: 8 monthsPosted 4.8 years ago

Interventions

ACE Inhibitors and Diureticsdrug

Hctz/Lisinopril (brand name: Zestoretic)

NIFEdipine ERdrug

Extended release nifedipine