CI

At a glance

ClinicalIndex Comparison Record
Early Ph 1Active· 161 enrolled / 161 target
Drug / intervention
Aspirin +1 moredrug
Likely dose
81 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05056896
NCT05056896Early Ph 1ActiveUpdate Overdue (3.3/mo)Completion was 19mo ago
CompareCT.gov

ASPIRED-XT: ASPirin Intervention for the REDuction of Colorectal Cancer Risk -EXTension

Massachusetts General Hospital·interventional·Posted Sep 27, 2021·Updated Jun 22, 2026

In Brief

A Early Phase 1 clinical trial evaluating Aspirin and Placebo for Colorectal Cancer. Active but no longer recruiting, targeting 161 participants across 1 site.

Signals

Enrollment appears stalled

Detailed Summary

This research study is studying a drug intervention as a possible chemoprevention strategy for colorectal cancer. The name of the study intervention involved in this study is: * Low Dose Aspirin

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsColorectal Cancer
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH)

Timeline

Early Ph 1Active
202220232024202520262027
First PostedSep 27, 2021
Enrollment StartJun 3, 2022
Primary CompletionNov 27, 2024
Study CompletionDec 31, 2026
TodayJul 2, 2026
Enrollment to primary: 2.5 yearsPosted 4.8 years ago

Arms & Interventions

Low Dose Aspirinexperimental

Participants will be randomly assigned to aspirin group and receive a daily low dose aspirin (81 mg) for the duration of the study up to 12 weeks.

Drug: Aspirin
Placeboexperimental

Participants will be randomly assigned to placebo group and receive a daily placebo capsule for the duration of the study up to 12 weeks.

Other: Placebo

Interventions

Aspirindrug

Capsule taken orally

Placeboother

Capsule taken orally