CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 52 enrolled
Drug / intervention
A: 40 Hz music +2 morebehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05064007
NCT05064007N/ACompleted
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The Power of Sound and Music Interventions for Older Adults With Mild Cognitive Impairment

Johns Hopkins University·interventional·Posted Oct 1, 2021·Updated Aug 29, 2025

In Brief

A clinical study evaluating A: 40 Hz music, B: 40 Hz sound, and 1 other intervention for Mild Cognitive Impairment. Completed, enrolled 52 participants across 1 site.

Detailed Summary

Emerging studies in humans found that 40 Hz sound induces neural gamma oscillation and enhanced cognitive function in older adults with and without Alzheimer's Disease. We will compare a 40 Hz music intervention to both 40 Hz sound and music alone in a clinical cohort of older adults with mild cognitive impairment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMild Cognitive Impairment
CountriesUnited States
CollaboratorsNational Institute on Aging (NIA)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedOct 1, 2021
Enrollment StartFeb 1, 2022
Primary CompletionApr 3, 2024
Study CompletionApr 3, 2025
TodayJul 2, 2026
Enrollment to primary: 2.2 yearsPosted 4.8 years ago

Interventions

A: 40 Hz musicbehavioral

The participant will listen to the 40 Hz music playlist one hour each day, 5 days a week for 4 weeks

B: 40 Hz soundbehavioral

The participant will listen to the 40 Hz sound playlist one hour each day, 5 days a week for 4 weeks

C: Preferred musicbehavioral

The participant will listen to the preferred music playlist one hour each day, 5 days a week for 4 weeks