CI

At a glance

ClinicalIndex Comparison Record
Phase 1Completed· 32 enrolled
Drug / intervention
FDC 12.5mg empagliflozin/850mg metformin +2 moredrug
Likely dose
FDC 12.5mg empagliflozin/850mg metforminfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05083949
NCT05083949Phase 1Completed

Relative Bioavailability of Empagliflozin/Metformin Fixed-dose Combination - Empagliflozin 12.5 mg + Metformin 850mg (Boehringer Ingelheim) Coated Tablet Versus Jardiance® 10mg (Reference 1: Boehringer Ingelheim) Coated Tablet and Glifage® 850mg (Reference 2: Merck S / A. ) Coated Tablet, Administered Together in Healthy Male and Female Subjects Under Fed Conditions: an Open-label, Randomised, Single-dose, Two-way Crossover Study

Boehringer Ingelheim·interventional·Posted Oct 19, 2021·Updated Jul 27, 2023

In Brief

A Phase 1 clinical trial evaluating FDC 12.5mg empagliflozin/850mg metformin, Empagliflozin, and 1 other intervention for Healthy. Completed, enrolled 32 participants across 1 site.

Detailed Summary

This trial is to establish bioequivalence of the fixed dose combination (FDC) tablets (containing 12.5 mg empagliflozin/850 mg metformin) (Test, T) compared with the single tablets (10 mg empagliflozin and Glifage® 850 mg tablets) (Reference, R).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsHealthy
CountriesBrazil
Collaborators--

Timeline

Phase 1CompletedFinished
20222023202420252026
First PostedOct 19, 2021
Enrollment StartJul 23, 2021
Primary CompletionAug 6, 2021
Study CompletionSep 9, 2021
TodayJul 2, 2026
Enrollment to primary: 13 daysPosted 4.7 years ago

Interventions

FDC 12.5mg empagliflozin/850mg metformindrug

empagliflozin/metformin

Empagliflozindrug

empagliflozin 10mg (R1)

Glifage®drug

Glifage® 850mg (R2)