At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
No Pharmacokinetic Interaction Between Chlorthalidone and Losartan, in Healthy Volunteers Under Fasting Conditions, Administered in Fixed Combination Against Individual Components Administered Jointly and Separately
In Brief
A Phase 1 clinical trial evaluating Chlorthalidone (HIGROTON® 50), Losartan (COZZAR®), and 2 other interventions for Healthy. Completed, enrolled 36 participants across 1 site.
Detailed Summary
Monocentric study of no pharmacokinetic interaction between chlorthalidone and losartan, with an open, randomized, single-dose design with four periods, four sequences and crossover in healthy volunteers, under fasting conditions, administered in fixed combination (Test product of Laboratorios Silanes, SA de CV) against the individual components administered jointly and separately (Higroton® 50, a product of Sandoz, SA de CV and Cozaar® , a product of Schering-Plow, SA de CV)
Study Details
Timeline
Interventions
Tablets with 50mg of Chlorthalidone, product de Sandoz, S.A. de C.V.
Losartan potassium 100 mg tablet, a product of Schering-Plough, S.A. C.V.
50mg chlorthalidone + 100 mg losartan potassium
Tablets with fixed combination of Chlorthalidone 25 mg and Losartan Potassium