At a glance
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The Prevalence of Local IgE Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population
In Brief
A Phase 3 clinical trial evaluating Intranasal capsaicin and topical lidocaine for Non-allergic Rhinitis. Completed, enrolled 28 participants across 1 site.
Detailed Summary
The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based on visual analog scale and optical rhinometry, to determine the prevalence of non-allergic rhinitis with local IgE elevation in this study's cohort of patients with non-allergic rhinitis identified by rhinitis history and negative skin testing for allergic rhinitis, and to determine the change, if any, in intranasal IgE levels after capsaicin treatment.
Study Details
Timeline
Interventions
Intranasal capsaicin, 5 applications each delivering 2 micrograms in each nostril, separated by 1 hour.
The nose will be pre-treated with topical lidocaine 15 minutes before each application