CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 25 enrolled
Drug / intervention
Axicabtagene Ciloleucel +6 morebiological
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05108805
NCT05108805Phase 4Completed

Safety and Feasibility Study of Chimeric Antigen Receptor (CAR) T Cell Therapy With YESCARTA in the Outpatient Setting

Vanderbilt-Ingram Cancer Center·interventional·Posted Nov 5, 2021·Updated Mar 27, 2025

In Brief

A Phase 4 clinical trial evaluating Telemedicine Visit, Vital sign measurements, and 5 other interventions for Large B-cell Lymphoma and Diffuse Large B-cell Lymphoma. Completed, enrolled 25 participants across 1 site.

Detailed Summary

We hope to demonstrate that YESCARTA can be safely administered in the outpatient setting if we closely monitor subjects with physical exams, wearable devices, and telemedicine visits and only admit those who meet specified criteria

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedNov 5, 2021
Enrollment StartDec 2, 2021
Primary CompletionDec 8, 2023
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 4.7 years ago

Interventions

Telemedicine Visitprocedure

A remote telemedicine visit with audio and video, using the internet with a nurse practitioner (NP) located elsewhere. The participant and NP will activate the telemedicine App in their electronic device. Family will obtain vital signs (BP, heart rate (HR), respiration rate (RR), SPO2) and provide NP with the information. NP will also review the previous vital signs. Review of system questions are asked, and the answers given by subject recorded. Neurological assessment done, and ICE score calculated.

Vital sign measurementsprocedure

Participant and their family will record and measure vital signs using a wearable device and will place a call to the covering nurse practitioner to report the vital signs prior to reporting to the out patient visit.

Out-Patient Clinic Visitprocedure

Physical exam and review of all available data

Blood pressure and pulse oximeterprocedure

Participant and their family take their blood pressure and pulse oximeter

Axicabtagene Ciloleucelbiological

Axicabtagene Ciloleuce given by IV

Cyclophosphamidedrug

Given IV

Fludarabinedrug

Given IV