CI

At a glance

ClinicalIndex Comparison Record
Phase 2Recruiting· 170 target
Drug / intervention
Magnetic Resonance Imagingother
Likely dose
Not stated in record
Key inclusion· 8
  • ✓Histologically confirmed breast cancer with documented ER/PR/HER2 status
  • ✓Stage IV extracranial disease in HR+/HER2- patients who progressed after first-line therapy
  • ✓Stage IV extracranial disease in triple-negative and HER2+ patients
  • ✓Age 18 years or older
Key exclusion· 6
  • ✕Prior diagnosis or treatment of brain metastases or leptomeningeal disease
  • ✕Prior non-breast malignancy with evidence of disease within 2 years
  • ✕Neurologic symptoms requiring brain MRI at enrollment
  • ✕Indications for brain MRI due to other neurologic conditions at study entry

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05115474
NCT05115474Phase 2RecruitingOn Track
Long Recruiting
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Phase II Study of Screening Brain MRIs in Stage IV Breast Cancer

H. Lee Moffitt Cancer Center and Research Institute·interventional·Posted Nov 10, 2021·Updated May 18, 2026

In Brief

A Phase 2 clinical trial evaluating Magnetic Resonance Imaging for Triple Negative Breast Cancer and 2 related conditions. Currently recruiting, targeting 170 participants across 2 sites.

Detailed Summary

The study is a single arm, nonrandomized phase II prospective study, with the goal of investigating the role of screening brain MRIs in neurologically asymptomatic patients with metastatic breast cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTriple Negative Breast Cancer, HER2-positive Breast Cancer, Hormone Receptor-positive Breast Cancer
CountriesUnited States
CollaboratorsFlorida Breast Cancer Foundation

Timeline

Phase 2Recruiting
20222023202420252026
First PostedNov 10, 2021
Enrollment StartDec 21, 2021
Primary CompletionJun 16, 2026
Study CompletionOct 1, 2026
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 4.6 years ago

Interventions

Magnetic Resonance Imagingother

Participants will undergo MRI imaging with and without contrast.