CI

At a glance

ClinicalIndex Comparison Record
N/ARecruiting· 200 target
Drug / intervention
preoperative radiosurgery +1 moreradiation
Likely dose
Not stated in record
Key inclusion· 13
  • ✓Age 18 years or older
  • ✓Karnofsky performance status at least 60
  • ✓Histological diagnosis of malignant primary or metastatic tumor
  • ✓Ability to tolerate steroids
Key exclusion· 11
  • ✕Radiosensitive histology: germ cell tumor, lymphoma, multiple myeloma
  • ✕Greater than 10 mm midline shift or effacement of 4th ventricle
  • ✕More than 4 brain metastases or target metastasis diameter greater than 4.0 cm
  • ✕More than 1 metastasis requiring resection

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05124236
NCT05124236N/ARecruitingHigh MomentumUpdated 3mo ago
Long Recruiting
CompareCT.gov

A Multicenter Prospective, Interventional, Randomized Trial of Preoperative Radiosurgery Compared With Postoperative Stereotactic Radiotherapy for Resectable Brain Metastases

Susanne Rogers·interventional·Posted Nov 17, 2021·Updated Mar 4, 2026

In Brief

A clinical study evaluating preoperative radiosurgery and postoperative hypofractionated stereotactic radiotherapy for Brain Metastases, Adult. Currently recruiting, targeting 200 participants across 10 sites in 3 countries.

Signals

Enrolling ahead of pace

Detailed Summary

The research question is whether a single fraction of preoperative radiosurgery can reduce the incidence of leptomeningeal disease 12 months following resection of a brain metastasis (BM) as compared with 5 fractions of postoperative stereotactic radiotherapy.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Metastases, Adult
CountriesAustria, Germany, Switzerland
CollaboratorsUniversity of Basel

Timeline

N/ARecruiting
20222023202420252026202720282029
First PostedNov 17, 2021
Enrollment StartJul 29, 2022
Primary CompletionDec 30, 2028
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 4.6 years agoPrimary completion in 2.5 years

Interventions

preoperative radiosurgeryradiation

single fraction radiosurgery

postoperative hypofractionated stereotactic radiotherapyradiation

fractionated stereotactic radiotherapy /radiosurgery in 1 to 6 fractions according to local standard of care