CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 714 enrolled
Drug / intervention
Indirect calorimetryother
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05124860
NCT05124860N/ACompleted
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A Longitudinal Investigation of Energy Expenditure and Substrate Utilization in Critically Ill Patients: a Prospective Observational Multi-center Study

Karolinska University Hospital·observational·Posted Nov 18, 2021·Updated Apr 11, 2025

In Brief

An observational study evaluating Indirect calorimetry for Critical Illness. Completed, enrolled 714 participants across 7 sites in 4 countries.

Detailed Summary

The metabolic alterations associated with critical illness have significant implications for the nutritional management of ICU patients. Despite this, little is known about these changes in patients requiring prolonged organ support and nutritional therapy. The overall aim of this study is to describe changes in metabolism over time in a large prospective cohort of patients requiring \>10 days of ICU care. Our hypothesis is that there is a significant change in mean energy expenditure and respiratory quotient (RQ) between the early (day 1-3), intermediate (day 4-10) and late (\>10 days) phase in ICU.

Study Details

Study Typeobservational
Allocation--
Masking--
Primary Purpose--
ConditionsCritical Illness
CountriesAustralia, Netherlands, Sweden, Switzerland
CollaboratorsKarolinska Institutet

Timeline

N/ACompletedFinished
20222023202420252026
First PostedNov 18, 2021
Enrollment StartFeb 21, 2022
Primary CompletionJul 18, 2024
Study CompletionMar 21, 2025
TodayJul 2, 2026
Enrollment to primary: 2.4 yearsPosted 4.6 years ago

Interventions

Indirect calorimetryother

Measurement of metabolic rate (kcal/day) by respiratory gas analysis.