CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 21 enrolled
Drug / intervention
Cannabidiol (CBD) oral solution +2 moredrug
Likely dose
Cannabidiol (CBD) oral solution 2.5mlfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05132699
NCT05132699Phase 2Completed
CompareCT.gov

Enhancing Prolonged Exposure With Cannabidiol to Treat Posttraumatic Stress Disorder: A Pilot Study

The University of Texas Health Science Center at San Antonio·interventional·Posted Nov 24, 2021·Updated Oct 10, 2024

In Brief

A Phase 2 clinical trial evaluating Cannabidiol (CBD) oral solution, Placebo, and 1 other intervention for Posttraumatic Stress Disorder and Stress Disorders, Post-Traumatic. Completed, enrolled 21 participants across 1 site.

Detailed Summary

The primary goal of this pilot project is to demonstrate the safety and feasibility of using Cannabidiol (CBD) in combination with standard of care prolonged exposure (PE) psychotherapy to reduce PTSD symptoms.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPosttraumatic Stress Disorder, Stress Disorders, Post-Traumatic
CountriesUnited States
CollaboratorsNational Center for Advancing Translational Sciences (NCATS)

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedNov 24, 2021
Enrollment StartApr 4, 2022
Primary CompletionJun 30, 2023
TodayJul 2, 2026
Enrollment to primary: 1.2 yearsPosted 4.6 years ago

Interventions

Cannabidiol (CBD) oral solutiondrug

An oral strawberry flavored liquid, taken as a 2.5ml (250mg) dose twice a day

Placebodrug

An inert strawberry flavored oral solution, taken as a 2.5ml dose twice a day

Massed Prolonged Exposure (mPE)behavioral

mPE, delivered daily Monday through Friday over two weeks, utilizes exposure-based interventions to target psychological mechanisms (i.e., experiential and behavioral avoidance; maladaptive cognitive changes) that are thought to maintain trauma-related symptoms.