At a glance
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Iron, Transferrin and Retinopathy of Prematurity (ROP): Towards New Pathophysiological Mechanisms.
In Brief
An observational study evaluating Plasma determination of iron, transferrin and ferritin and Fundus Examination by wide field digital imaging camera (PanocamTM camera) for Retinopathy of Prematurity. Completed, enrolled 175 participants across 3 sites.
Detailed Summary
The purpose of this study is to determine whether increased transferrin saturation in plasma (that reflects iron overload and/or low transferrin) is an independent risk factor for ROP development and severity. Preterm infants born at \<31 week's post-menstrual age (PMA) or ≤1250g of birth weight will be included. Iron parameters in plasma will be measured during the first month of life. Retinopathy of prematurity (ROP) will be screened as currently recommended. The relationship between plasma iron parameters and ROP development and/or severity will be established.
Study Details
Timeline
Interventions
Iron, transferrin and ferritin levels in plasma
ROP screening using wide field digital retinal imaging according to current recommendations.