CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 79 enrolled
Drug / intervention
Active TBS-DLPFC +2 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05144789
NCT05144789N/ACompleted
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Personalized Therapeutic Neuromodulation for Anhedonic Depression

Stanford University·interventional·Posted Dec 3, 2021·Updated Mar 18, 2026

In Brief

A clinical study evaluating Active TBS-DLPFC, Active TBS-DMPFC, and 1 other intervention for Treatment Resistant Depression. Completed, enrolled 79 participants across 1 site.

Detailed Summary

This study will investigate the anti-anhedonic efficacy of a novel neurostimulation strategy termed accelerated intermittent theta burst stimulation (aiTBS) in participants with treatment resistant depression (TRD).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTreatment Resistant Depression
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
20222023202420252026
First PostedDec 3, 2021
Enrollment StartMay 31, 2022
Primary CompletionJun 6, 2025
Study CompletionDec 31, 2025
TodayJul 2, 2026
Enrollment to primary: 3.0 yearsPosted 4.6 years ago

Interventions

Active TBS-DLPFCdevice

Participants in the active stimulation group will receive intermittent TBS to left DLPFC. The L-DLPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004). Stimulation will be delivered to the L-DLPFC using a MagPro TMS system (MagVenture, Denmark).

Active TBS-DMPFCdevice

Participants in the active stimulation group will receive intermittent TBS to DMPFC. The DMPFC will be targeted utilizing the Localite neuronavigation system. Stimulation intensity will be standardized at 90% of RMT and adjusted to the skull to cortical surface distance (see Nahas 2004). Stimulation will be delivered to the DMPFC using a MagPro TMS system (MagVenture, Denmark).

Sham TBS-DLPFC or DMPFCdevice

The parameters in the sham arm will be as above with the internal randomization of the device internally switching to sham in a blinded fashion.