At a glance
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Perioperative Pain-control With Parecoxib in Uniportal Video-assisted Thoracoscopic Surgery.
In Brief
A Phase 4 clinical trial evaluating Parecoxib and Placebo for Perioperative Care and Chronic Post-operative Pain. Completed, enrolled 58 participants across 1 site.
Detailed Summary
Chronic pain after thoracic surgery has been a bothering problem since the era of thoracotomy. The prevalence of chronic pain no matter in thoracotomy or video-assisted thoracoscopic surgery is about 30 to 47%. Better acute pain control after thoracic surgery has been assumed to be an effective way for prevention of chronic pain. Especially in this extreme minimal invasive surgery, uniportal video-assisted thoracic surgery, more optimized perioperative analgesics should be found out. In the guideline of "enhanced recovery after surgery", less opioid is suggested. Other than opioids, there are just few parental analgesics could be used, like acetaminophen or cyclooxygenase-2(COX-2) inhibitor. In our study, the investigators would like to build up a better analgesic strategy for uniportal video-assisted thoracoscopic surgery with less opioid and less side effects.
Study Details
Timeline
Interventions
Parecoxib 40mg will be administered to the experimental group if the patient has no contraindication.
This is normal saline 2ml, which is equal to the volume of parecoxib solution. Placebo will be injected to placebo group 15 minutes before the end of the surgery.