At a glance
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The Optimal Ultrafiltration Protocol in Pediatric Cardiac Surgery: An Observational Cohort Study
In Brief
An observational study evaluating SBUF-SMUF for Congenital Heart Disease and Inflammation. Completed, enrolled 40 participants across 1 site.
Detailed Summary
Infants and children undergoing cardiac surgery with cardiopulmonary bypass (CPB) can experience systemic inflammation that prolongs post-operative recovery. Ultrafiltration is an intra-opreative technique that is hypothesized to extract circulating inflammatory mediators during the CPB time. There have been only a few small studies looking at a limited number of inflammatory marker profiles in this context. Our institution uses an innovative form of ultrafiltration "subzero-balance simple-modified ultrafiltration" (SBUF-SMUF) throughout the entire CPB time. SBUF-SMUF has been our standard of care for the last 5 years. This observational seeks to describe the clinical and immunologic outcomes of infants and children undergoing cardiac surgery with CBP and SBUF-SMUF.
Study Details
Timeline
Arms & Interventions
All patients underwent standard of care cardiac surgery, cardiopulmonary bypass and SBUF-SMUF with effluent removal of 30 ml/kg/hr and physiologic solution replacement of 25ml/kg/hr.
Interventions
Intra-operative continuous ultrafiltration