CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 404 enrolled
Drug / intervention
Revefenacin +3 moredrug
Likely dose
Revefenacin 175 mcgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05165485
NCT05165485Phase 4Completed

A Phase 4, Randomized, Double-Blind, Double-Dummy, Parallel-Group, Study Comparing Improvements in Lung Function in Adults With Severe to Very Severe Chronic Obstructive Pulmonary Disease and Suboptimal Inspiratory Flow Rate Following Once-Daily Treatment Over 12 Weeks With Either Revefenacin Inhalation Solution Delivered Via Standard Jet Nebulizer or Tiotropium Delivered Via a Dry Powder Inhaler (Spiriva® HandiHaler®)

Theravance Biopharma·interventional·Posted Dec 21, 2021·Updated Dec 20, 2024

In Brief

A Phase 4 clinical trial evaluating Revefenacin, Tiotropium, and 2 other interventions for Chronic Obstructive Pulmonary Disease. Completed, enrolled 404 participants across 76 sites.

Detailed Summary

Study is a randomized, double-blind, double-dummy, parallel-group study evaluating efficacy and safety of revefenacin vs. tiotropium in adults with severe to very severe COPD and suboptimal PIFR.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
CollaboratorsViatris Inc.

Timeline

Phase 4CompletedFinished
20222023202420252026
First PostedDec 21, 2021
Enrollment StartJan 7, 2022
Primary CompletionNov 13, 2023
Study CompletionNov 20, 2023
TodayJul 2, 2026
Enrollment to primary: 1.8 yearsPosted 4.5 years ago

Interventions

Revefenacindrug

Revefenacin 175 mcg administered once daily for 84 days via nebulization

Tiotropiumdrug

Tiotropium 18 mcg administered once daily for 84 days via Spiriva HandiHaler®

Revefenacin Placebodrug

Placebo for Revefenacin administered once daily for 84 days via nebulization

Tiotropium Placebodrug

Placebo for Tiotropium administered once daily for 84 days via Spiriva HandiHaler®