At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Targeted HD-tDCS for Reducing Post-stroke Movement Impairments
In Brief
A clinical study evaluating Transcranial direct current stimulation (high-definition) for Stroke. Completed, enrolled 14 participants across 1 site.
Detailed Summary
Stroke is the leading cause of serious, long-term disability. The emergence of abnormal muscle synergies following a stroke presents a major limitation to the recovery of independent function. Despite the development of many interventions for movement recovery post-stroke, rehabilitation treatments are minimally effective to the muscle synergy impairment. Previous studies have found that muscle synergy impairment is associated with the damage to the corticospinal tract and the maladaptive recruitment of the contralesional cortico-reticulospinal tract. The investigators hypothesize that facilitating the damaged cortico-spinal tract (via primary motor cortex) and/or inhibiting the contralesional cortico-reticulospinal tract (via dorsal premotor cortex) will reduce muscle synergy impairment. In this pilot project, the investigators propose to run a proof-of-concept pilot trial to evaluate the effect of the targeted high-definition transcranial direct current stimulation (HD-tDCS) on mitigating muscle synergy impairment.
Study Details
Timeline
Interventions
Three conditions (2 mA, 20 mins): 1. anodal stimulation over the ipsilesional primary motor cortex 2. cathodal one over the contralesional premotor cortex 3. Sham