At a glance
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Antiviral Efficacy of Oral Rinses for Inactivation of COVID-19 (MOR2)
In Brief
A clinical study evaluating Placebo Comparator: Sterile Water, 27% Ethanol plus essential oils, and 1 other intervention for COVID-19 and 2 related conditions. Completed, enrolled 230 participants across 1 site.
Detailed Summary
Randomized, double-blind prospective trial to test the efficacy of therapeutic, antiseptic mouth rinses to inactivate severe acute respiratory syndrome coronavirus (SARS-CoV-2) in saliva of COVID-19 positive patients aged 18-65 years old. All mouthrinses are commercially available and will be used according to on-label instructions. Patients will be randomized to a mouthrinse and will be asked to give a saliva sample immediately before and after a one minute mouthwash. Saliva samples will be collected from patients at 15 minute intervals thereafter up to an hour (15, 30, 45 and 60 minutes). The samples will be stored and used for real-time reverse transcription polymerase chain reaction (RT-PCR) detection of viral SARS-CoV-2 RNA and viral infectivity assays. Patients will also complete a short-survey on the taste and experience of using the mouthwash. This study involves 150 subject participants and one, 75-90 minute visit.
Study Details
Timeline
Interventions
Sterile Water Placebo Comparator
Over-the-counter antiseptic mouth rinse
Over-the-counter antiseptic mouth rinse