CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 19 enrolled
Drug / intervention
7-day sleep labbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05180279
NCT05180279N/ACompleted
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The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis

Rush University Medical Center·interventional·Posted Jan 6, 2022·Updated Aug 19, 2025

In Brief

A clinical study evaluating 7-day sleep lab for Ulcerative Colitis. Completed, enrolled 19 participants across 1 site.

Detailed Summary

The purpose of this study is to investigate if circadian malalignment (unusual sleeping patterns), such as night shifts (sleeping during the day and being awake during the night time), worsens the inflammation of the gut. We hope to look at patients with Ulcerative Colitis and Healthy Controls.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsUlcerative Colitis
CountriesUnited States
CollaboratorsNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJan 6, 2022
Enrollment StartApr 1, 2021
Primary CompletionJun 5, 2024
TodayJul 2, 2026
Enrollment to primary: 3.2 yearsPosted 4.5 years ago

Interventions

7-day sleep labbehavioral

Patients will stay in 7-day sleep lab where light exposure, diet, and activity will be closely monitored. They will have two unprepped flexible sigmoidoscopies with rectal biopsy collection and stool collection. Cycles will be shifted by 12h once on Day 3 of sleep lab and be discharged after an 8 hour sleep session on Day 7.