CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 174 enrolled
Drug / intervention
Transcranial direct current stimulation +1 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05202119
NCT05202119N/ACompleted
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Empower: Transcranial Direct Current Stimulation in Major Depressive Disorder: a Double-blind, Placebo-controlled, Randomized, Superiority Trial

Flow Neuroscience AB·interventional·Posted Jan 21, 2022·Updated Apr 22, 2026

In Brief

A clinical study evaluating Transcranial direct current stimulation and Sham Transcranial direct current stimulation for Major Depressive Disorder. Completed, enrolled 174 participants across 2 sites in 2 countries.

Detailed Summary

A two-center trial to investigate whether or not active stimulation with the Flow FL-100 tDCS device is superior to sham stimulation for the treatment of major depressive disorder when used at home. Participants perform up to 36 tDCS sessions by themselves without supervision during a blinded 10-week phase, and then 30 more sessions during an unblinded open-label phase.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder
CountriesUnited Kingdom, United States
CollaboratorsUniversity of Texas, University of East London

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJan 21, 2022
Enrollment StartMay 12, 2022
Primary CompletionJun 6, 2023
Study CompletionAug 31, 2023
TodayJul 2, 2026
Enrollment to primary: 1.1 yearsPosted 4.4 years ago

Interventions

Transcranial direct current stimulationdevice

Transcranial direct current stimulation (tDCS) a non-invasive brain stimulation technique where a weak direct current (2 mA) is applied on the scalp through electrodes. The current modulates the underlying neural activity. The sessions are 30 minutes, 3-5 time a week.

Sham Transcranial direct current stimulationdevice

To blind the participants of the stimulation, a standardized sham protocol is used where the current ramped up and then down breifly in the beginning and end of each session to simulate active stimulation.