CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 71 enrolled
Drug / intervention
Theta-frequency near-zero phase lag stimulation +5 moredevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05204381
NCT05204381N/ACompleted
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Causal Role of Theta and Alpha Oscillations in Output-gating

University of North Carolina, Chapel Hill·interventional·Posted Jan 24, 2022·Updated Nov 20, 2025

In Brief

A clinical study evaluating Theta-frequency near-zero phase lag stimulation, Theta-frequency anti-synchrony stimulation, and 4 other interventions for Executive Function. Completed, enrolled 71 participants across 1 site.

Detailed Summary

The participants will perform a cognitive control task. During the task, rhythmic trains of transcranial magnetic stimulation will be delivered to the prefrontal cortex and parietal cortex. Participants will be screened for their ability to perform the task. Magnetic resonance imaging will be used to localize regions of interest to be targeted. Electroencephalography will be collected concurrent with stimulation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsExecutive Function
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJan 24, 2022
Enrollment StartJan 24, 2022
Primary CompletionDec 20, 2024
TodayJul 2, 2026
Enrollment to primary: 2.9 yearsPosted 4.4 years ago

Interventions

Theta-frequency near-zero phase lag stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in theta-frequency (approximately 6 Hz) with a near-zero phase lag.

Theta-frequency anti-synchrony stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in theta-frequency (approximately 6 Hz) with a 180 degree phase offset, anti-synchrony.

Arrhythmic near-zero phase lag stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in an arrhythmic pattern with a near-zero phase lag matched in duration to the rhythmic stimulation for that session.

Arrhythmic independent stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in different independent arrhythmic patterns matched in duration to the rhythmic stimulation for that session.

Alpha-frequency near-zero phase lag stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in alpha-frequency (approximately 10 Hz) with a near-zero phase lag.

Alpha-frequency anti-synchrony stimulationdevice

Rhythmic transcranial magnetic stimulation (TMS) is delivered to both frontal and parietal cortex in alpha-frequency (approximately 10 Hz) with a 180 degree phase offset, anti-synchrony.