CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 160 enrolled
Drug / intervention
CBT4CBT COPESbehavioral
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05204576
NCT05204576N/ACompleted

Computer Based Treatment for Cognitive Behavioral Therapy and Cooperative Pain Education and Self-Management

Yale University·interventional·Posted Jan 24, 2022·Updated May 1, 2026

In Brief

A clinical study evaluating CBT4CBT COPES for Opioid Use Disorder and Chronic Pain. Completed, enrolled 160 participants across 3 sites.

Detailed Summary

The investigators plan to develop and pilot test an integrated, web-based cognitive behavioral approach and then conduct a randomized clinical trial evaluating its efficacy relative to standard care in a large and diverse sample of individuals with chronic pain treated with buprenorphine or methadone. The new program will retain key components of Dr. Carroll's computer-based training for cognitive-behavioral therapy (CBT4CBT), including its emphasis on teaching cognitive and behavioral coping skills in an engaging way and focus on the 5 A's of MAT (Adherence, Attendance, Abstinence, Alternate Activities and Accessing support); it will add components from Dr. Heapy's COPES (Cooperative Pain Education and Self-Management) intervention (self-management of chronic pain, with daily surveys via text that monitor pain intensity and interference, physical activity, and skills practice) and modify existing CBT4CBT modules to address the complex interplay between pain and drug use in this population, emphasizing the development of generalizable skills. A randomized clinical trial evaluating CBT4CBT-COPES will be conducted in a diverse sample 160 of individuals enrolled in agonist treatment (methadone or buprenorphine) who have chronic pain, in a 3-month randomized clinical trial with a 6-month follow-up, comparing it to standard treatment alone. The primary retention outcome will be adherence with agonist treatment; the primary pain outcome will be the PROMIS 6-item Pain Interference Short Form.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
20222023202420252026
First PostedJan 24, 2022
Enrollment StartJul 15, 2022
Primary CompletionMar 21, 2025
TodayJul 2, 2026
Enrollment to primary: 2.7 yearsPosted 4.4 years ago

Interventions

CBT4CBT COPESbehavioral

Individuals will receive standard agonist treatment plus access to the CBT4CBT-COPES website plus daily IVR assessment calls