CI

At a glance

ClinicalIndex Comparison Record
Phase 1Recruiting· 52 target
Drug / intervention
Insulin, 4 units +5 moredrug
Likely dose
Insulin, 4 unitsfrom record
Key inclusion· 3
  • ✓Capable of providing informed consent
  • ✓Diagnosis of optic neuropathy (glaucoma, NAION, or optic disc drusen)
  • ✓Only one eye per patient selected; if both qualify, select eye with worse acuity and/or visual field
Key exclusion· 6
  • ✕Pregnant or breastfeeding
  • ✕Ocular pathologies other than glaucoma contributing to severe vision loss
  • ✕Glucose intolerance, type 1 or 2 diabetes mellitus
  • ✕Unable to perform reliable visual field

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05206877
NCT05206877Phase 1RecruitingOn TrackUpdated 7mo ago
Long Recruiting
CompareCT.gov

Topical Insulin for Glaucoma and Optic Neuropathies

Stanford University·interventional·Posted Jan 25, 2022·Updated Nov 25, 2025

In Brief

A Phase 1 clinical trial evaluating Insulin, 4 units, Insulin, 20 units, and 4 other interventions for Glaucoma. Currently recruiting, targeting 52 participants across 1 site.

Detailed Summary

The purpose of this Phase 1 trial is to determine the safety over 1-2 months of topic sterile human recombinant insulin on subjects with optic neuropathies (glaucoma, ischecmic optic neuropathy, and optic disc drusen).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsGlaucoma
CountriesUnited States
Collaborators--

Timeline

Phase 1Recruiting
202220232024202520262027
First PostedJan 25, 2022
Enrollment StartApr 1, 2022
Primary CompletionDec 31, 2026
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 4.4 years agoPrimary completion in 6 months

Interventions

Insulin, 4 unitsdrug

Topical insulin 100 U/ml, 1 drop per day

Insulin, 20 unitsdrug

Topical insulin 500 U/ml, 1 drop per day

insulin, 4 units twice dailydrug

1 drop of low dose insulin twice daily.

insulin, 20 units twice dailydrug

1 drop of high dose insulin twice daily

insulin, 4 units three times dailydrug

1 drop of low dose insulin three times daily.

insulin, 20 units three times dailydrug

1 drop of high dose insulin three times daily.