CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 95 enrolled
Drug / intervention
ATI-450 +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05216224
NCT05216224Phase 2Completed

A Phase 2a, Randomized, Double-blind, Placebo-controlled Study to Investigate the Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of ATI-450 vs Placebo in Patients With Moderate to Severe Hidradenitis Suppurativa (HS)

Aclaris Therapeutics, Inc.·interventional·Posted Jan 31, 2022·Updated Jan 7, 2026

In Brief

A Phase 2 clinical trial evaluating ATI-450 and Placebo oral tablet for Hidradenitis Suppurativa. Completed, enrolled 95 participants across 20 sites.

Detailed Summary

This is a Phase 2a study to investigate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of ATI-450 vs placebo in patients with moderate to severe Hidradenitis Suppurativa (HS).

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedJan 31, 2022
Enrollment StartDec 29, 2021
Primary CompletionDec 23, 2022
Study CompletionJan 24, 2023
TodayJul 2, 2026
Enrollment to primary: 12 monthsPosted 4.4 years ago

Interventions

ATI-450drug

Oral, small molecule MK2 inhibitor

Placebo oral tabletdrug

Placebo tablet manufactured to match ATI-450 in appearance