CI

At a glance

ClinicalIndex Comparison Record
Phase 2Active· 53 enrolled
Drug / intervention
Tafasitamab +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05222555
NCT05222555Phase 2Active

A Phase 1b/2, Open-Label, Multicenter Study to Evaluate the Safety and Pharmacokinetics of a Modified Tafasitamab IV Dosing Regimen Combined With Lenalidomide in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Incyte Corporation·interventional·Posted Feb 3, 2022·Updated Jan 16, 2026

In Brief

A Phase 2 clinical trial evaluating Tafasitamab and Lenalidomide for Diffuse Large B Cell Lymphoma. Active but no longer recruiting, targeting 53 participants across 62 sites in 9 countries.

Detailed Summary

This is an open-label, multicentre study too Evaluate the Safety and Pharmacokinetics of a Modified Tafasitamab IV Dosing Regimen Combined with Lenalidomide (LEN) in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL) who have had at least one, but no more than three prior systemic regimens and who are not eligible for high dose chemotherapy (HDC) with autologous stem-cell transplantation (ASCT) at the time of study entry.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesAustria, Czechia, France, Israel, Italy, Poland, South Korea, Spain, United States
Collaborators--

Timeline

Phase 2Active
2022202320242025202620272028
First PostedFeb 3, 2022
Enrollment StartJul 19, 2022
Primary CompletionJul 17, 2024
Study CompletionNov 30, 2027
TodayJul 2, 2026
Enrollment to primary: 2.0 yearsPosted 4.4 years ago

Interventions

Tafasitamabdrug

tafasitamab will be administered intravenously at protocol defined timepoints

Lenalidomidedrug

lenalidomide will be administered orally at protocol defined timepoints