At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Optimization of Positive End-expiratory Pressure During Laparoscopic Surgery
In Brief
A clinical study evaluating Respiratory monitoring, Capnography, and 2 other interventions for Post-Op Complication and Ventilator-Induced Lung Injury. Completed, enrolled 60 participants across 1 site.
Detailed Summary
Lung-protective ventilation (LPV) during general anesthesia can trigger the development of early postoperative pulmonary complication (PPC) and ventilator associated lung injury. One of the proven components of the LPV is low tidal volume (TV). Data on the positive end-expiratory pressure (PEEP) parameters adjustment in laparoscopic surgery, as well as the effects on the respiratory biomechanics, lung tissue and respiratory muscles damage are limited and not clear. The objective of the study is to evaluate the ability of the esophageal pressure (Pes) based controlled personalized PEEP adjustment, to improve the biomechanics of the respiratory system and oxygenation due to laparoscopic cholecystectomy.
Study Details
Timeline
Interventions
Measurement of the plateau pressure, positive end-expiratory pressure, driving pressure, end-expiratory lung volume, compliance of respiratory system on volume-controlled ventilation
Measurement of end-tidal carbon dioxide tension, volume of CO2 eliminated per minute
Measurement of the oxygen partial pressure and the carbon dioxide partial pressure
Measurement the pressure in the lower third of esophagus during inspiration and expiration