CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 385 enrolled
Drug / intervention
Placebo +2 moredrug
Likely dose
Emraclidine 10 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT05227690
NCT05227690Phase 2Completed

A Phase 2, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy, Safety, and Tolerability of Two Fixed Doses (10 mg and 30 mg QD) of CVL-231 (Emraclidine) in Participants With Schizophrenia Experiencing an Acute Exacerbation of Psychosis

AbbVie·interventional·Posted Feb 7, 2022·Updated Sep 17, 2025

In Brief

A Phase 2 clinical trial evaluating Placebo, Emraclidine 10 mg, and 1 other intervention for Schizophrenia. Completed, enrolled 385 participants across 25 sites in 2 countries.

Detailed Summary

This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, parallel-group, 6-week trial to evaluate the efficacy, safety, and tolerability of 2 fixed doses of CVL-231 (Emraclidine) (10 mg QD and 30 mg QD) in male and female participants who have schizophrenia and are experiencing an acute exacerbation of psychosis.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSchizophrenia
CountriesBulgaria, United States
Collaborators--

Timeline

Phase 2CompletedFinished
20222023202420252026
First PostedFeb 7, 2022
Enrollment StartJun 30, 2022
Primary CompletionAug 23, 2024
Study CompletionAug 26, 2024
TodayJul 2, 2026
Enrollment to primary: 2.1 yearsPosted 4.4 years ago

Interventions

Placebodrug

Matching placebo, oral (tablet), once per day for 6 weeks

Emraclidine 10 mgdrug

Emraclidine 10 mg, oral (tablet), once per day for 6 weeks

Emraclidine 30 mgdrug

Emraclidine 30 mg, oral (tablet), once per day for 6 weeks